The development of new CBD veterinary therapeutics
Broad-spectrum extract has a very low THC content, well below that of full-spectrum hemp. I first developed broad-spectrum hemp products five or six years ago in the infancy of the pet CBD craze. It was an important way to ensure the safety of these extracts for use in dogs. Over time, we have placed more than 500,000 units of various products in the hands of veterinarians, and individual reports show that the THC content of these formulations was minimal to no detrimental effect, and effectiveness in osteoarthritis, epilepsy and anxiety the three most dominant Applications for pet CBD.
Anecdotes, however, are not the same as unbiased, placebo-controlled, blinded research into a product’s effectiveness. To this end, we are in the middle of a study at a veterinary rehab hospital in Austin, Texas to measure the effectiveness of our broad spectrum extract on naturally occurring osteoarthritis in dogs.
We are currently in the open part of the study and will then move into the double-blind, placebo-controlled crossover phase. In contrast to existing published studies, real arthritis measurements are used here: force plate analyzes of the load on the affected limb; digital thermography to assess the heat and subsequent inflammation of the affected joint; C-reactive protein (CRP) measurements to measure whole body inflammation; Hyaluronic acid levels, which are an assessment of osteoarthritis; as well as veterinary assessment of gait disorders and video recording of the improvement in mobility before and after mobility in each subject.
It is important to note that in every study published so far, the rodent isolate dose has been 2 mg / kg twice a day, which is four times the recommended dosage on the label of our veterinary products. So, in addition to validating the effectiveness of broad-spectrum hemp extracts for OA in the dog, this study will use a dose that is a quarter of the dose used in rodent studies. If this research reflects what we anecdotally hold to be true, it means people can extend the use of CBD oil products to two to four times longer lifespans. That would be quite a savings in the long run to keep your beloved dogs moving and happy.
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Isolate is significantly cheaper than whole plant extracts and most studies, aside from an in vitro study on isolated cell lines compared to human cancer, show that whole plant extracts are effective at a much lower dose. For this reason, the rodent dose of the pain isolate is four times higher than that of the whole plant extract. When the FDA finally looks into regulating cannabis, many who know about how the FDA works think that it will regulate isolates intended to be used by drug companies and whole plant extracts intended to be used by those who make dietary supplements manufacture and OTC products.
Based on the studies published for veterinary species, laboratory species, and humans, it appears that whole plant extracts can do the same thing as isolates at a lower dose. Even if isolates cost less, the fact that they require a higher dose can negate any cost benefits for their use.
As long as isolates are on the market, pet owners will buy them and may offer benefits comparable to those of whole plant extracts or broad spectrum extracts. Whether they (isolates, whole plant extracts) are interchangeable from species to species, from individual to individual or from condition to condition has yet to be proven objectively. In terms of safety, they are comparable at the same dosages, as far as we could judge with the currently available studies.
To use my personal experience as an example of products I am associated with, I recommend using extract with low to no THC content. This reflects my concern about reported animal reactions to THC. These reactions may be due to an individual’s sensitivity to THC; poor analysis of the extract; or the high dose of CBD, which brings increased amounts of THC that could cause a reaction.